IGF-1 RELEASE IN THE MEDIAL PREFRONTAL CORTEX MEDIATES THE RAPID AND SUSTAINED ANTIDEPRESSANT-LIKE ACTIONS OF KETAMINE

IGF-1 release in the medial prefrontal cortex mediates the rapid and sustained antidepressant-like actions of ketamine

Abstract Ketamine, an N-methyl-D-aspartate receptor antagonist, exerts rapid and sustained antidepressant actions.Preclinical studies demonstrated that the release of brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor in the medial prefrontal cortex (mPFC) is essential for the antidepressant-like effects of ketamine.How

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Maximal nonlocality from maximal entanglement and mutually unbiased bases, and self-testing of two-qutrit quantum systems

Bell inequalities are an Toy important tool in device-independent quantum information processing because their violation can serve as a certificate of relevant quantum properties.Probably the best known example of a Bell inequality is due to Clauser, Horne, Shimony and Holt (CHSH), which is defined in the simplest scenario involving two dichotomic

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The coexistence of hermaphroditic and dioecious plants is associated with polyploidy and gender dimorphism in Dasiphora fruticosa

Dasiphora fruticosa comprises male, female and hermaphrodite plants, which are distributed sympatrically in some populations on the Qinghai-Tibet Plateau.To explore what governs the coexistence of these three sexual phenotypes, we investigated Plein air - Homme - Chaussures - Soulier the DNA contents, pollen and ovule production, pollen deposition,

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